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  1. #1
    Join Date
    Apr 2012
    Location
    USA, NJ
    Posts
    43

    Default Mottling in eye(s)

    When we agreed to take Q into our family we were aware he was diagnosed with Retinopathy/PRA while he was in Finland.

    Fortunately for Q we had a second opinion performed by Dr. Aguirre of the University of Pennsylvania this past Sunday and his determination was it is simply mottling/discoloration that is apparently not uncommon with this breed as they age. They do not know what causes it but stated it is not a inherited condition.

    He does have some small cataracts in his left eye but they should not adversely affect his vision.

    Has anyone else had any experience with this mottling?

    On a side note he stated they are getting very close to determining the gene that causes PRA in Basenji's and developing a test for it, hopefully sooner than later we can be rid of it in the breed.

  2. #2
    Join Date
    Jun 2008
    Location
    USA, Ohio
    Posts
    1,210

    Default

    I have never heard of it and I tried to do a search on it but could not find anything. How old is your boy? My rescue girl who is 9 has a cataract in one eye and she gets seen by an opthalmologist every one or two years to make sure the cataract has not changed. So far, they have been able to see around it so she does not need surgery. She is the one that catches birds!

    I have had older Basenjis with retinal changes but have never had one with PRA and this includes just about all of the rescues I have had since the mid 90s. What age does PRA usually develop in Basenjis? Is PRA common in Basenjis?

    Jennifer

  3. #3
    Join Date
    Apr 2012
    Location
    USA, NJ
    Posts
    43

    Default

    Q will be 8 years old in November.

    The BCOA has this information to offer on PRA and it states anywhere from 3 to 13 years on average:
    https://www.basenji.org/joomla/index...Itemid=292#PRA

    I think it's hard to say how common it is as I have no idea what % of the dogs out there are getting the CERF exams.
    I believe I read it is most prevalent in male Huskies, but Basenji's are also said to be prone to it. I wish I knew more but that is why I am here asking those that know more than I

    I was just curious if anyone else out there had a false positive like we did. I am just so happy I won't have to deal with our new son having to go down that road (really it's me being selfish, the dog would handle it fine, I'd be a wreck).

  4. #4
    Join Date
    Jul 2006
    Location
    Northern California
    Posts
    11,246

    Default

    It is a genetic concern in Basenjis and has been, breeders have been aware of PRA for years. Where did you hear that they were close to finding the gene? No one in the US has heard this? Who is it that is claiming this? EDIT.... I just read your post that you got your boy from Chris. She posted on another list about "close to a gene for PRA" and many on that list posted asking for more information since none of us has heard this....

    And yes, false positive is not uncommon in our breed. It is also been called "bronzing". Since many do not report their CERF exams to OFA, there is no real way to know the % of Basenjis that may have PRA. There are certain bloodlines that we know carry the gene and have either had it themselves or produced it in offspring.

    As breeders we think that it is (and hoping) it is recessive, but nothing has been proven yet.... and IMO, not enough people have their old dogs CERF'ed so we do not have good information
    Pat Fragassi
    Tanza Basenjis
    www.tanzabasenjis.net

  5. #5
    Join Date
    Apr 2012
    Location
    USA, NJ
    Posts
    43

    Default

    This is who mentioned it, it is the doctor that did the examination and is involved in the research AFAIK:

    http://www.vet.upenn.edu/FacultyandD...culty_id=20894

  6. #6
    Join Date
    Jun 2008
    Location
    USA, Ohio
    Posts
    1,210

    Default

    Charlie and I had a couple of older rescues, ages 5-8, that were misdiagnosed. They were later found to have age related retinal changes. I had them rechecked by an opthalmologist at the Indy National who was familiar with Basenjis because I thought it was odd that these dogs had the same diagnosis-PRA. None of them were related. My Arnie who is 11 also has age related retinal changes.

    I believe Dr. Aguirre is speaking at the Basenji National in Gettysburg this year. I am hoping to attend.

    Jennifer

  7. #7
    Join Date
    Nov 2009
    Location
    MA
    Posts
    1,347

    Default

    Well, congratulations is in order, a misdiagnosis in your case turned out to be a great thing! And good for you for accepting Q despite knowing ( at the time) he had PRA, I doubt it's an easy thing to face head on. So glad for Q!
    "I know I've found the breed for me because he totally turns my life upside down and I love it!"

  8. #8
    Join Date
    Jul 2006
    Location
    Northern California
    Posts
    11,246

    Default

    Thanks for that.. interesting that no one else in the Basenji Fancy is aware of this... ... sorry, but unless this is linked to the breed, I would wonder as the U of Mo that did all the Fanconi tested to get to the direct gene is the one that have been getting DNA samples from PRA dogs and/or offspring/families
    Pat Fragassi
    Tanza Basenjis
    www.tanzabasenjis.net

  9. #9
    Join Date
    Dec 2006
    Location
    VA
    Posts
    39

    Default

    Quote Originally Posted by tanza View Post
    Since many do not report their CERF exams to OFA, there is no real way to know the % of Basenjis that may have PRA. There are certain bloodlines that we know carry the gene and have either had it themselves or produced it in offspring.

    As breeders we think that it is (and hoping) it is recessive, but nothing has been proven yet.... and IMO, not enough people have their old dogs CERF'ed so we do not have good information
    Couple of quick comments - for determining percentage of dogs affected, it doesn't matter if people report their CERF exams to OFA or CERF or not. There are other good reasons to do that, but statistics are not one of them. CERF statistical reports, which are what you would use to try to show the incidence, show the entire set of all dogs that received CERF exams, whether their owners sent in the forms to CERF or to OFA or not.

    A wide range of bloodlines have either had PRA or produced it in their offspring - the focus on certain bloodlines is generally misleading. Unless breeders are routinely testing at an advanced age - and very few are - you really don't know what you do or do not have.

    The biggest problem, when you look at the statistical reports - which again, are complete for all dogs receiving CERF exams - is that so few older dogs are getting CERF exams. The issue isn't incomplete reports, since CERF tallies every single CERF exam from the practitioner forms, not the forms the owner sends in. The issue is an extremely small sample set that may or may not be representative.

  10. #10
    Join Date
    Dec 2006
    Location
    VA
    Posts
    39

    Default

    Quote Originally Posted by tanza View Post
    Thanks for that.. interesting that no one else in the Basenji Fancy is aware of this... ... sorry, but unless this is linked to the breed, I would wonder as the U of Mo that did all the Fanconi tested to get to the direct gene is the one that have been getting DNA samples from PRA dogs and/or offspring/families
    Drs Acland and Aguirre have been collecting DNA samples from PRA dogs and their families since the 1980's. Everett and Karen Pashley did test breedings for them in the 1980's and 1990's, and Everett wrote many articles on it.

    In the 1990's and 2000's, I worked with breeders with a variety of bloodlines to help put together related clusters. This effort included having the Drs A speak, arranging clinics for eye exams and and blood collection, and driving dogs up to Kennett Square, where Dr Acland also works. Dr Acland spoke at the 1996 National, and had a large and well attended eye clinic there where they took blood samples. We have had organized attendance at their other eye clinics, not just at Nationals, and they've taken DNA samples there. I wrote several articles for it and for a while we had a special PRA committee dedicated to raising funds and collecting samples. If you remember the Basenji PRA pins that Damara Bolte created, that was part of that effort.

    In the late 90's or early 2000's, Betty White, Toni Ackerman, I think Carolyn Rollins, and I drove a large number of dogs - not our own dogs, but dogs related to specific dogs the researchers were interested in - up to PA. That trip was sort of a Basenji PRA express, with dogs collected from pet owners and breeders across a fairly wide area, picked up, driven to Kennett Square, examined and sampled, and then dropped back off.

    Several breeders have been working with them steadily for many years. The Drs A have collected samples of any dog of interest.

    I would guess they have the largest collection of Basenji PRA DNA samples in the world. Things have been quiet for a long while, but they certainly have the sample set to do impressive research.

    Parenthetically, the doctor speaking at Nationals is Acland, not Aguirre.

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